The two fierce rivals Manchester United and Liverpool will meet at Old Trafford in the FA Cup fourth round on the weekend of January 22-25, just a week after their top-of-the-table Premier League clash at Anfield.
Non-league Chorley will host Premier League Wolverhampton Wanderers after beating a depleted Derby County in the third round.
League Two Cheltenham Town are set to welcome Pep Guardiola’s Manchester City to Whaddon Road.
The fourth-round ties will be played the weekend of 23-24 January.
Everton – who haven’t won a trophy since their 1995 FA Cup triumph – will take on Sheffield Wednesday.
Crawley Town, who celebrated a famous 3-0 win over Leeds United on Sunday, will travel to Championship side Bournemouth in the next round.
Jose Mourinho’s Tottenham will face Wycombe Wanderers at Adams Park, while Fulham take on Burnley in an all-Premier League tie.
Swansea host Nottingham Forest, with Barnsley to face Norwich in another all Championship match.
Chorley would face 14-time winners Arsenal in the fifth round – if the National League North side overcome Wolves and the Gunners beat either Southampton or Shrewsbury.
David Moyes could return to former club Manchester United in the last 16 if West Ham beat League One Doncaster Rovers and United seal victory over Liverpool in the fourth round.
FA Cup fourth-round draw
Cheltenham Town v Manchester City
Bournemouth v Crawley Town
Swansea City v Nottingham Forest
Manchester United v Liverpool
Southampton/Shrewsbury v Arsenal
Barnsley v Norwich
Chorley v Wolves
Millwall v Bristol City
Brighton v Blackpool
Wycombe v Tottenham
Fulham v Burnley
Sheffield United v Plymouth
Chelsea v Luton
West Ham v Doncaster
Brentford v Leicester
Everton v Sheffield Wednesday
The fifth-round ties will be played 9-11 February.
FA Cup fifth-round draw:
Fifth round fixtures have been penciled in for Wednesday, February 10.
Fulham/Burnley v Bournemouth/Crawley Town
Manchester United/Liverpool v West Ham or Doncaster
Sheffield United/Plymouth v Millwall/Bristol City
Chorley/Wolves v Southampton/Shrewsbury or Arsenal
Barnsley/Norwich v Chelsea/Luton Town
Everton/Sheffield Wednesday v Wycombe/Tottenham
Swansea City/Nottingham Forest v Cheltenham Town/Manchester City
Brentford/Leicester v Brighton/Blackpool